Question on Organophosphate poisoning

“I’m confused about Organophosphate poisoning/AChE inhibitor overdose in terms of whether you give pralidoxime first to start replenishing AChE or give Atropine first to stabilize the cholinergic overactivity first.  I’m getting conflicting answers.”


Unquestionably, the MOST important thing about an acute overdose of organophosphates is to give ATROPINE. If the question has a choice of BOTH atropine and praladoxime, this would be ideal, however if there is a choice between these two, then ATROPINE in unquestionably the right answer.

Good Luck!!



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